Alternative Options Archives

At he IACFS/ME meetings in Ottawa, Canada in September, 2011, three studies on GcMAF therapy in CFS cases were presented by Kenny DeMeirleir MD, PhD out of Belgium and by Paul R. Cheney MD, PhD out of NC.   GcMAF is a partially deglycosylated vitamin-D binding protein also know as Gc protein.  The functional change in the Gc protein caused by serial deglycosylation is known as GcMAF or Gc Macrophage Activating Factor. GcMAF is made naturely in the body under certain conditions of immune activation but can also be made outside the body by chemical or laboratory means and by the use of certain probiotics in a Yogurt-like mixture in your own kitchen.   GcMAF is extremely potent and will at very low concentrations activate, regulate and expand macrophages which are the central processing unit of the immune system and capable of modulating and controling both the innate and cognate immune systems.

Three GcMAF studies presented in Ottawa showed improvement in CFS symptoms using a similar patient-centered assessment instrument.  Dr. DeMeirleir, using an injectable (IV or SQ) chemically derived GcMAF given at 100 ng on a weekly basis, showed at 63% response rate (68/108) over 5-40 weeks of therapy.  Dr. Cheney used a similarly manufactured chemical GcMAF in 19 patients treated at 100 ng every 5 days over 8 weeks by SL route but he also used, in a separate study, a novel probiotic-based GcMAF given by oral daily route (MAF 314) developed by Prof’s Ruggiero and Pacini out of Florence, Italy.  The SL chemical GcMAF demonstrated a response rate of 79% (15/19) over at least 8 weeks while the probiotic-based oral GcMAF (MAF 314) demonstrated a 76% (16/21) response rate over only 28 days.  Given the lower numbers and shorter time frames in Dr. Cheney’s two studies, there was likely no significant difference between the three studies in terms of overall response rate in CFS patients.  However, there appeared to be differences in the chemical GcMAF response rate that depended on the patient’s vitamin-D VDR polymorphisms that was not seen in the probiotic GcMAF (MAF 314) and positive response rates were generally seen much quicker in the probiotic GcMAF (MAF 314).  There were mild to moderate side effects seen in all three studies and generally responded to dose reduction as well as other measures.  GcMAF, given by a number of different routes, appears to be an effective therapy for well defined CFS patients.

JeffBradstreetBy Kent Heckenlively, Esq.

Although my daughter is not a patient of Dr. Jeff Bradstreet I’ve always had an enormous amount of respect for the good doctor.  I’ll usually go on his website once or twice a month to find out what has most recently attracted his interest.  Often it seems we’re looking at similar questions; which either means great minds think alike, or we suffer from some of the same delusions.

I was intrigued by his October 11, 2011 entry, “An Update on Viral Issue in Autism” since it dovetailed with some of my own recent investigations.

In the past months Dr. Bradstreet has become interested in nagalese, which he describes as an enzyme “produced by cancer cells and viruses.”  He thinks it unlikely that children with autism have undiagnosed cancers, and thus suspicion falls on a viral etiology.  Dr. Bradstreet writes, “Viruses make the nagalese enzyme as part of their attachment proteins.  It serves to get the virus into the cell and also decreases the body’s immune reaction to the virus-thereby increasing the odds of viral survival.”

Further on Dr. Bradstreet writes, “It is reasonable and likely that the nature of the immune dysfunction and the frequently observed autoimmune problems in autism are mediated by persistent, unresolved viral infections.”  He claims to have tested approximately 400 children with autism for the viral marker, nagalese, and found that nearly 80% have significantly elevated levels.  He hopes to publish soon on this study and believes this information “is one of the most important developments in the clinical treatment of children on the spectrum that I have experienced in the last 15 years.”

Dr. Bradstreet’s article got my attention because of my daughter’s own nagalese testing.  I had her tested back in May (when she’d endured three hospitalizations due to uncontrolled seizures) and her reading was 3.3 (reference range 0.35-0.95).  In desparation we tried the ketogenic diet (high fats and low carbs), and although there have been some rough patches since May we have avoided further hospitalizations.

And her stools normalized.

Yes, I know all of you realize how important that is.  We’re talking months and months of good stools.  Seizures down at least 80%.  So of course, your friendly neighborhood science teacher was interested in what her nagalese levels might be, so we did a retest in late September.  This time her reading was 1.7.  It was about a 50% drop, and while it’s still abnormal, it is progress.  It makes me wonder if a low-carb diet starves viruses of an energy source.

There are critics of nagalese testing.  Dr. Enlander, a specialist in chronic fatigue syndrome/ME, another disease which may be viral in origin, doesn’t believe the tests are sensitive enough to be of any value.  And he may be right.

Dr. Bradstreet also discusses a substance called GcMAF, which I don’t have enough information about to make an informed judgment, and that after viral clearance, the possibility of using neuronal stem cells which can cross the blood-brain barrier.  I really can’t comment on the advisability of either suggestion.

But if you are like me, still looking for that clue which might help your child join the ranks of the recovered, you might investigate nagalese.

Kent Heceknlively is a Contributing Editor to Age of Autism

earthing productsEarthing

I have been earthing for about 6 months now. I started with the full fitted king size bed sheet. I can’t say there has been any crazy results BUT i certainly do sleep better using the earthing sheet. So that in it’s self is pretty significant I guess.

Just recently I had a friend call me and he said he was earthing up to 20 hours a day. I was like how do you do that. He has the earthing sheet plus an earthing mat and earthing mouse pad. Also when he goes out side he tries to go outside in his bare feet so he is getting the benefits from the earth.

By using the earthing mat and mouse pad and walking in his bare feet outside he is able to get close to 20 hours a day. This is when he really started noticing some big time results from earthing.

So I just recently bought the earthing mat and mouse pad. I am on the computer a lot. So now I am grounded when i am on the computer:) This should help me with EMF’s and also get be grounded 15-17 hours a day.

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Earthing Benefits

  • so simple, safe and natural
  • improves health in general,
  • improves immunity
  • eliminates the causes of inflammation and chronic inflammatory diseases such as arthritis
  • improves relaxation and sleep
  • reduces stress while increasing energy
  • relieves tension in muscles
  • improves blood flow

In other words, it promotes optimal health and body function.

Earthing Products

There are many different type of earthing products to help you get grounded. Below are a few

  • earthing sheets
  • earthing pad
  • earthing mat
  • earthing bed pad
  • earthing connection universal mat
  • earthing shoes
  • earthing mouse pad

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Judy A. Mikovits, the embattled scientist who led the research team that found a possible link between the retrovirus XMRV and patients with chronic fatigue syndrome, has been terminated from her job as director of research at the Whittemore Peterson Institute for Neuro-Immune Disease in Reno, Nev.

The controversial finding, published in a 2009 Science paper, excited patients and researchers who have long been searching for a cause for chronic fatigue syndrome, which has an array of debilitating symptoms that include cognitive difficulties, severe pain, and overwhelming fatigue. On Sept. 22, the authors of the paper, including Mikovits, published a partial retraction of the findings in Science, after two of the 13 study authors found contamination in blood samples from patients.

A week later, Mikovits was fired, she told Health Blog.

In a letter from Whittemore Peterson President Annette Whittemore to Mikovits, which was reviewed by Health Blog, Mikovits was terminated after refusing Whittemore’s direct request that cell lines be turned over to another scientist at the institute who wanted to do research on them.

In a letter of response, Mikovits said that the cells were for use in a specific NIH-funded project and that it would be inappropriate to use them for another purpose without her knowledge and consent.

Whittemore told the Health Blog that she and Mikovits were “not seeing eye-to-eye” on who controlled the cells. Research on retroviruses and their possible connection to CFS as well as other diseases continues, she said. “We will keep going down that path as long as it continues to show promise,” Whittemore says.

Mikovits is a principal investigator on an ongoing NIH-funded study that will test CFS patients and healthy controls for XMRV or related viruses, and she said that she plans to take her grant with her to a new institution where she wants to continue her work on CFS.

But like many things in the long-running XMRV saga, this may not be simple. Whittemore says that the institute wants to continue to participate in the NIH study and has “the research capacity, the lab and the researchers” to follow through on the work. In terms of the fate of that grant, “‘it is an NIH call,” Whittemore says.

The benefits of magnesium are numerous and vital to the body’s optimal functioning, but most people fail to appreciate the value of this essential macromineral. The National Academy of Sciences recommends a daily dietary intake of magnesium at 350mg per day for adults, but data from national health surveys reveal that an estimated 68% of Americans fail to get the suggested amounts of magnesium in their diets. It’s time the benefits of magnesium are shoved under the spotlight to help people be aware of the need for this mineral in achieving health.

  1. One of the benefits of magnesium is that it protects against cardiovascular diseases. Certain dietary surveys and some studies have suggested that adequate magnesium intake is associated with a decreased risk of coronary heart disease and a lowered risk of having a stroke. There is also evidence that insufficient magnesium in the body increases the risk of abnormal heart rhythms, raising the risk of complications after heart attack. The benefits of magnesium in this respect can be attributed to the fact that magnesium plays a central role in muscle relaxation, and lack in magnesium can cause the heart muscle to develop spasms and abnormal rhythms.
  2. Another of the benefits of magnesium is that it plays an important role in natural blood pressure regulation. The DASH (Dietary Approaches to Stop Hypertension) study suggested that a diet emphasizing vegetables, fruits and low fat dairy food—the kind of diet high in magnesium, calcium, and potassium—can significantly lower or prevent high blood pressure.
  3. What’s more, included among the benefits of magnesium is that it lowers the risk of developing Type 2 Diabetes and the complications of diabetes such as retinopathies. Magnesium does so by playing a role in carbohydrate metabolism and influencing the activity of insulin, a hormone responsible for blood glucose regulation.
  4. Also note that one of the benefits of magnesium is that it can help alleviate muscle aches, spasms and cramps. While calcium is the one responsible for contracting muscles, magnesium is in charge of relaxing them. Magnesium deficiency, therefore, can tense up the muscles and give rise to muscle pains and discomforts.
  5. Furthermore, because of magnesium’s effect on muscle relaxation, prevention of asthma attacks is also among the benefits of magnesium. Asthma attacks manifest when the bronchial airways narrow, and magnesium can come to the rescue by relaxing the bronchial muscles, therefore widening the airway and improving breathing.
  6. Among all the benefits of magnesium, one of the most important is its ability to lower the risk of osteoporosis, a bone condition marked by severely reduced bone density. Magnesium affects the way calcium is preserved and utilized in the body, and multiple research studies have already proven that calcium supplemented with magnesium can improve bone mineral density.

 

The benefits of magnesium mentioned here are just some the most important ones, but the list can go on. Add in prevention of constipation, treatment of insomnia and migraines, preservation of a healthy immune system, and maintenance of normal nerve function as among the benefits of magnesium. Indeed, adequate intake of magnesium is the secret to optimum health, a key to achieving that inner balance everybody should have.

This is a good magnesium drink

 

Japanese Knotweed

Japanese Knotweed (Polygonum cuspidatum) is an increasingly prolific and invasive plant species that has spread across much of the US including upstate New York and the Adirondacks. It is considered a noxious weed in New York State and eradication programs have been enacted in the Adirondacks with herbicides being one of the main weapons of mass destruction. The plant resembles bamboo, but is actually in the buckwheat family (Polygonaceae) and is native in South Central Asia and Japan. Japanese knotweed  spreads aggressively through its rhizome with even small pieces growing into plants.

It chooses to grow along the edges of fields, waterways, and roads with a particular fondness for disturbed areas where there was once toxic waste of sorts. It is a perennial and grows up to 6ft. high with broadly ovate leaves and white, cascading flowers and hollow stems. This is the bad news…

The good news is that Japanese Knotweed is a highly medicinal and edible plant that is currently being used as treatment for Lyme disease. We can also use as much as we want of this plant being that it is so highly invasive, allowing us to reduce our use of native or non-invasive plants.The young shoots are a food source that can be steamed and boiled like asparagus. The root/rhizome is gathered in the Spring or Fall and contains a variety of medicinal constituents used traditionally to treat everything from eczema to bronchitis and stalled labor.

One of the main compounds of Japanese Knotweed is resveratrol, also found in red grape skins (red wine) among  many other plants, and, according to herbalist David Hoffmann, can “modulate multiple molecular pathways thought to be associated with the development and progression of cardiovascular disease and cancer….” Resveratrol is considered antioxidant, antimutagenic and inhibits platelet aggregation. It is particularly appropriate in the treatment of Lyme arthritis as, with Lyme being a spirochete, the arthritis is incited by the production of specific proteins that stimulate pathways that do not respond to treatment by other herbal anti-inflammatories.

The whole plant contains several other constituents and, when taken to treat Lyme disease and it’s symptoms, has proven to be very effective in bringing  relief to many people suffering from the disease and its coinfections. Japanese Knotweed tastes bitter and sour with energetics being cold and dry. It is considered stimulating and astringent. Japanese Knotweed  has also, according to herbalist Stephen Buhner, been proliferating across bioregions immediately preceding the emergence of Lyme disease.

I have witnessed this occurrence in the area of central New York State where I live. I  heard Stephen speak at a conference about this about 5 years ago and, at the time, I had minimal knowledge or experience with Lyme disease and its treatment. I had also never seen a Japanese knotweed plant. I began to notice them in my locality about 4 years ago and, even then, it was only sparsely on  the edges of roads and in vacant lots where houses or small industries used to exist. It has spread dramatically in the last three years simultaneously with the abundant increase in deer ticks . The ticks have been slowly increasing as the winters have been slowly getting warmer.

Japanese Knotweed

The herb has a long list of medicinal uses especially as a broad-spectrum antibacterial and has been found effective against spirochetes including Borrelia burdorferi(Lyme). It is an antiviral, immunomodulator, immunostimulant, laxative, diuretic, expectorant, antitussive and a capillary stimulant. The capillary stimulant action is of specific importance in Lyme treatment as it increases the blood flow to areas where the Lyme spirochete likes to live such as the eyes, skin, heart and joints.

This then helps to carry the medicinal constituents of any treatments to those places. This makes it a great addition to any Lyme treatment formula/protocol. It should not be taken  in pregnancy except in small doses and should not be used with other blood thinners.

I have been taking Japanese Knotweed this summer in a preventative formula for myself. I contracted Lyme disease last year and have, fortunately, been symptom free and feeling healed since about December.  Because there is not any way to accurately test to see if I still have it, as Lyme can encyst or hide itself, I can only continue to maintain a healthy lifestyle and try to avoid getting run down where my immune system could be compromised. I also, naturally, try to avoid getting another tick bite because it is a disease that can be contracted repeatedly.

Invasive plants are undoubtedly a challenge to our ecosystems and can create a great deal of damage to native plant populations as some are quite imperialistic. They can also be seen for the gifts they offer that are seemingly appropriate to some of our new and emerging illnesses. For more information on the positive side of invasive species there is a book soon to be available called Invasive Plant Medicine The Ecological Benefits and Healing Abilities of Invasives by Timothy Lee Scott. I personally can’t wait to read it!! It is expected to be out sometime in August and you can pre-order at http://invasiveplantmedicine.com/

Sources for this article:
Healing Lyme by Stephen Buhner

Medical Herbalism by David Hoffmann

Jade Remedies by Peter Holmes

Materia Medica: Japanese Knotweed by Chris Marano in the Journal of the Northeast Herbal Association Winter/Spring 2010

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